Martin Schrappe Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

1/2022	Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.
11/2021	MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia.
10/2021	Genetic Variation in ABCC4 and CFTR and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.
4/2021	Blinatumomab in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
3/2021	Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data.
1/2021	Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia.
1/2021	Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.
1/2021	Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group.
4/2020	Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia.
1/2020	Methotrexate-associated toxicity in children with Down syndrome and acute lymphoblastic leukemia during consolidation therapy with high dose methotrexate according to ALL-BFM treatment regimen.

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Martin Schrappe Research Topics

Disease

107	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 01/2001
36	Leukemia 01/2022 - 04/2003
32	Residual Neoplasm 01/2021 - 12/2002
26	Neoplasms (Cancer) 01/2022 - 07/2002
20	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 06/2002
9	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021 - 07/2002
6	Pathologic Complete Response 01/2021 - 02/2006
5	Philadelphia Chromosome 12/2018 - 11/2010
4	Hypersensitivity (Allergy) 01/2022 - 01/2011
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 01/2004
4	Infections 04/2015 - 09/2004
3	Down Syndrome (Down's Syndrome) 01/2020 - 10/2008
3	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 01/2001
3	T-Cell Leukemia (Leukemia, T Cell) 07/2012 - 11/2008
3	Neuroblastoma 01/2011 - 09/2004
2	Aneuploidy (Aneuploid) 08/2021 - 12/2019
2	Brain Neoplasms (Brain Tumor) 01/2021 - 08/2009
2	Second Primary Neoplasms (Neoplasms, Second) 01/2021 - 11/2011
2	Genetic Predisposition to Disease (Genetic Predisposition) 11/2019 - 11/2013
2	Osteonecrosis (Kienbock's Disease) 01/2019 - 10/2018
2	Central Nervous System Diseases (CNS Diseases) 01/2017 - 02/2005
2	Glucocorticoid Receptor Deficiency 04/2010 - 04/2009
1	Pancreatitis 10/2021
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2021
1	Chromosome Aberrations (Chromosome Abnormalities) 04/2020

Drug/Important Bio-Agent (IBA)

14	Pharmaceutical PreparationsIBA 01/2020 - 06/2002
10	Prednisone (Sone)FDA LinkGeneric 01/2021 - 11/2003
9	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 12/2002
9	Proteins (Proteins, Gene)FDA Link 06/2018 - 11/2003
8	Asparaginase (Elspar)FDA Link 01/2022 - 01/2011
7	Methotrexate (Mexate)FDA LinkGeneric 01/2020 - 02/2005
6	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2017
6	Imatinib Mesylate (Gleevec)FDA Link 12/2018 - 09/2012
6	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2018 - 12/2002
6	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 12/2002
5	AntibodiesIBA 01/2022 - 01/2011
5	pegaspargase (Oncaspar)FDA Link 03/2021 - 03/2013
5	Biological ProductsIBA 11/2019 - 10/2007
5	Dexamethasone (Maxidex)FDA LinkGeneric 12/2017 - 06/2002
5	GlucocorticoidsIBA 04/2010 - 11/2003
4	Etoposide (VP 16)FDA LinkGeneric 01/2021 - 09/2005
3	Messenger RNA (mRNA)IBA 10/2020 - 05/2010
3	Phosphotransferases (Kinase)IBA 01/2020 - 04/2010
3	Tyrosine Kinase InhibitorsIBA 11/2018 - 03/2014
3	Biomarkers (Surrogate Marker)IBA 10/2018 - 06/2013
3	AntigensIBA 01/2018 - 01/2012
3	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2013 - 01/2005
3	EnzymesIBA 11/2011 - 03/2005
2	daratumumabIBA 01/2022 - 01/2019
2	MicroRNAs (MicroRNA)IBA 11/2021 - 01/2017
2	blinatumomabIBA 04/2021 - 01/2019
2	ChromatinIBA 01/2020 - 11/2019
2	Transcription Factors (Transcription Factor)IBA 12/2019 - 01/2018
2	CytokinesIBA 12/2019 - 10/2008
2	ProteomeIBA 12/2019 - 06/2013
2	Dasatinib (BMS 354825)FDA Link 11/2018 - 01/2017
2	Small Interfering RNA (siRNA)IBA 06/2018 - 01/2015
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2017 - 09/2005
2	ruxolitinibIBA 01/2017 - 09/2016
2	Janus Kinase InhibitorsIBA 09/2016 - 10/2008
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 02/2016 - 03/2005
2	Interleukin-15 (Interleukin 15)IBA 05/2015 - 10/2007
2	Thymidylate SynthaseIBA 06/2013 - 03/2003
2	Interleukin-7 (Interleukin 7)IBA 05/2011 - 06/2002
2	Cytokine Receptors (Cytokine Receptor)IBA 05/2011 - 07/2010
2	dinutuximabIBA 01/2011 - 09/2004
2	Rituximab (Mabthera)FDA Link 07/2010 - 02/2006
2	Cytarabine (Cytosar-U)FDA LinkGeneric 07/2010 - 07/2007
2	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 08/2009 - 03/2005
2	Lymphotoxin-alpha (Lymphotoxin)IBA 06/2009 - 01/2001
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2009 - 01/2001
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 04/2009 - 11/2003
2	Codon (Codons)IBA 01/2005 - 07/2002
1	venetoclaxIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Dacarbazine (DIC)FDA LinkGeneric 08/2021
1	Busulfan (Busulfex)FDA Link 01/2021
1	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2021
1	AnthracyclinesIBA 01/2021
1	treosulfanIBA 01/2021
1	Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric 01/2021
1	Thioguanine (Tioguanine)FDA Link 01/2021
1	fludarabineIBA 01/2021
1	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2021
1	Type II Tumor Necrosis Factor ReceptorsIBA 10/2020

Therapy/Procedure

58	Therapeutics 01/2022 - 01/2001
30	Drug Therapy (Chemotherapy) 01/2022 - 12/2002
15	Stem Cell Transplantation 01/2021 - 05/2004
13	Hematopoietic Stem Cell Transplantation 01/2021 - 01/2004
7	Radiotherapy 01/2021 - 01/2006
6	Aftercare (After-Treatment) 01/2021 - 04/2003
4	Immunotherapy 01/2022 - 05/2004
4	Cranial Irradiation 09/2009 - 01/2004
3	Homologous Transplantation 01/2019 - 06/2008
3	Transplantation 01/2016 - 06/2008
3	Ligation 11/2015 - 03/2013
3	Remission Induction 11/2013 - 01/2011
2	Induction Chemotherapy 01/2020 - 06/2009
2	Heterologous Transplantation (Xenotransplantation) 01/2020 - 08/2011
2	Combination Drug Therapy (Combination Chemotherapy) 08/2011 - 01/2009